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Febuxostat prevented propofol-induced expression of cyclooxygenase-2 (COX-2) and the production of prostaglandin E2 (PGE2). Cells were stimulated with 2% propofol in the presence or absence of febuxostat (10, 20 μM) for 24 h. (A) mRNA of COX-2. (B) Protein of COX-2 as measured using Western blot analysis. (C) Production of PGE2 (####P < 0.0001 vs the vehicle group; **P < 0.01, ***P < 0.001 vs the propofol group, n = 6).
