Table 3.
Comparison of mean radiation dose to the lungs, heart and female breasts for WM and UM volumes
| Mean Dose (Gy) | PTV distribution | DIBH median (range) | FB median (range) | Individual patient differences (FB – DIBH)/FB (median, range (%) | p- value |
|---|---|---|---|---|---|
| Lungs | WM (n = 26) | 10.9 (6.1–17.8) | 12.3 (6.4–16.9) | 9.6 (−7.5- + 23.2) | 0.001 |
| UM (n = 9) | 7.6 (5.9–10.8) | 8.8 (6.4–14.1) | 12.8 (−5.6- + 29.5) | 0.021 | |
| Heart | WM (n = 26) | 11.9 (4.8–23.8) | 11.3 (4.1–23) | −1.9 (−102.4–+44.8) | 0.611 |
| UM (n = 9) | 4.3 (1.4–8.7) | 4.9 (2–7.7) | 22.7 (−19.2 –+72.1) | 0.050 | |
| Breasts | WM (n = 12) | 5.7 (2.2–11.5) | 4.8 (1.8–12.2) | −9.9 (−88.9 –+10.6) | 0.110 |
| UM (n = 3) | 2 (0.9–2.4) | 2.1 (1.2–2.1) | 4.8 (−14.3- + 25) | 0.785 | |
| Left breast | WM (n = 12) | 5.4 (2–12.5) | 5.0 (1.9–13.7) | 0 (−78.9- + 16.8) | 0.507 |
| UM (n = 3) | 2.4 (1.0–2.8) | 2.6 (1.4–2.8) | 14.3 (−7.7- + 28.6) | 0.276 | |
| Right breast | WM (n = 12) | 4.8 (2.3–11.7) | 4.0 (1.7–10.6) | −28.2 (−100- + 19.2) | 0.012 |
| UM (n = 3) | 1.6 (0.8–2.1) | 1.4 (1.0–1.5) | −14.3 (−40- + 20) | 0.414 |
DIBH, deep inspiration breath-hold; FB, free breathing; PTV, planning target volume; UM, upper mediastinal; WM, whole mediastinum.