Table 2.
Summary of features of identified software of immediate interest. A checkmark represents an available feature, a checkmark in parentheses represents a partly available feature, a wave stands for a feature for which it is foreseen that the user includes it by writing additional code and an x represents an unavailable feature. Software is grouped into standalone software, packages for R and Stata and online trial simulators. MD Anderson is the abbreviation of Integrated Platform for Designing Clinical Trials
| Feature | Description | FACTS | ADDPLAN | EAST | OCTOPUS | nstage | MAMS | asd | HECT | MD Anderson |
|---|---|---|---|---|---|---|---|---|---|---|
| Flexibility arms | Options regarding the number of treatment arms at the start of the trial | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ |
| Staggered entry | Options regarding the staggered entry of treatments over time, such as pre-planned, randomly, replacing treatments, ... | x | x | x | ∼ | x | x | x | x | (✔) |
| Endpoints | Choice, e.g., binary, continuous, time-to-event | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ | x |
| Surrogate endpoint | Option to use different endpoint at interim | ✔ | (✔) | x | ∼ | ✔ | ✔ | ✔ | ✔ | x |
| Interims | Options regarding the number and timing of interim analyses | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ | x | ✔ | ✔ |
| Enrichment/seamless | Dedicated options for treatment selection or enrichment at interim | ✔ | ✔ | ✔ | ∼ | x | x | ✔ | x | x |
| Bayesian | Bayesian decision rules | ✔ | x | x | ✔ | x | x | x | ✔ | ✔ |
| Frequentist | Frequentist decision rules | ✔ | ✔ | ✔ | ∼ | ✔ | ✔ | ✔ | x | x |
| Flexibility data sharing | Advanced options for data sharing, such as sharing control data, sharing only concurrent control data, dynamic borrowing, etc. | x | x | x | (✔) | x | x | x | x | x |
| Multiplicity correction | Options for multiplicity correction, e.g., control of FWER, FDR, ... | x | ✔ | ✔ | ∼ | (✔) | ✔ | ✔ | x | x |
| Flexibility allocation ratio | Options regarding the allocation ratio of patients to the arms | ✔ | (✔) | (✔) | ∼ | ✔ | ✔ | x | (✔) | ✔ |
| RAR | Response-adaptive randomization | ✔ | x | x | ∼ | x | x | x | ✔ | ✔ |
| Flexibility cohort structure | Options for designing exact cohort structure to enter/leave platform, e.g., always control and two experimentals, ... | x | x | x | x | x | x | x | x | x |
| Flexibility recruitment rate | Options regarding the recruitment rate of patients to the trial | ✔ | (✔) | ✔ | ✔ | ✔ | x | x | x | x |
| Comparison classical development program | Built-in options regarding the comparison with more classical designs | x | x | x | x | x | x | x | (✔) | x |
| GUI | Graphical user interface | ✔ | ✔ | ✔ | x | ✔ | x | x | ✔ | ✔ |
| Commercial | Software is commercial | ✔ | ✔ | ✔ | x | x | x | x | x | x |
| Open Source | Open source code available | x | x | x | ✔ | ✔ | ✔ | ✔ | ✔ | x |