Table 1.
Characteristics of 50 patients with DM1
| Characteristics | Mean, SD, (Range) | Men (n 24) | Women (n 26) | Difference between men and women/Cohens d |
|---|---|---|---|---|
| Age, years | 40.1, SD: 12.6. (19–63) | 37, SD: 13.8 (19–63) | 43, SD: 10.7 (23–62) | ns |
| CTG kb N49 | 1.8, SD: 1.4 (0.230–5.4) | 1.3, SD: 1.1 (0.270–4.7) n24 | 2.3, SD: 1.5 (0.230–5.4) n25 | P = 0.008/0.8 |
| Disease duration, years | 19.0, SD: 10.0 (5–42) | 16.4, SD: 9.6 (5–42) | 21.5, SD: 9.7 (6–40) | ns |
| Mean strength of trunk muscles (MTT 0–3) | 1.7, SD: 0.5 (1–2.6) | 1.8, SD: 0.5 (1–2.6) | 1.6, SD: 0.4 (1–2.3) | ns |
| Mean strength of distal extremity (MTT 0–3) | 2.3, SD: 0.5 (1.5–3) | 2.3, SD: 0.5 (1.5–3) | 2.3, SD: 0.5 (1.5–3) | ns |
| Mean strength of proximal extremity (MTT 0–3) | 2.6, SD: 0.3 (2–3) | 2.7, SD: 0.3 (2–3) | 2.6, SD: 0.3 (2–3) | ns |
| Fatigue (FSS) Questionnaire N48 | 4.8, SD: 1.3 (2–7) | 4.5, SD: 1.6 (2–7) n23 | 4.9, SD: 1 (3–7) n25 | Ns / 0.33 |
| Walking test (6MWT) N45 | 382.4 SD:117.6 (123–615) | 417.5, SD:103.4 (123–523) n23 | 348.8, SD:122.8 (140–615) n22 | p = 0.049/0.60 |
| Katz ADL Questionnaire | [6.0] (3–6) | [5.5] (3–6) | [6.0] (4–6) | ns |
| Autism quotient index (AQ) Questionnaire N47 | 17.0, SD: 6.1 (6–32) | 19.4, SD: 5.4 (11–32) n21 | 15.0, SD: 6.1 (6–28) n 26 | p = 0.014 / 0.75 |
| IQ N41 | 92.0, SD: 14.2 (64–137) | 92.5, SD:17 (64–137) n20 | 91.5, SD: 11.4 (71–114) n21 | ns/ 0.06 |
| Anxiety (BAI) Questionnaire N43 | [4.0] (0–26) | [3.0] (0–26) n22 | [4.5] (0–23) n 22 | ns |
| Depression (BDI) Questionnaire N44 | [8.0] (0–37) | [7.0] (0–19) n21 | [8.0] (0–37) n 23 | ns |
| Respiration spirometry (FVC%) N 29 | 71.7, SD: 18.8 (25–103) | 76.4, SD: 14.0 (55–103) n13 | 67.9, SD: 21.6 (25–99) n16 | ns/ 0.77 |
| Quality of life (WHO QOL BREF) Questionnaire | 89.7, SD: 13.3 (59–115) | 91.3, SD: 12.4 (71–115) n24 | 88.2, SD:14.1 (59–114) n26 | ns/ 0.23 |
| BMI | 26.6, SD: 6.6 (15–53) | 26.3, SD: 5.5 (15–34) | 26.9, SD: 7.5 (17–53) | ns/0.09 |
Mean, [Median] SD, (min/max) are presented. Exact p-levels are given for differences < 0.05 between men and women and the Cohens d effect size is reported
DM1 Myotonic Dystrophy type 1, CTG Cytosine, Thymine, Guanine, MMT Manual Muscle strength test, FSS Fatigue Severity Scale, 6MWT Six-minute walk test, Katz ADL Assessment of Activities of Daily Living, IQ Intelligence quotient, BAI Becks Anxiety Inventory, BDI Becks Depression Inventory, FVC Forced Vital Capacity, WHOQOL BREF World health Organization Quality of Life Assessment, BMI Body mass index