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. 2020 Oct 29;112(3):227–247. doi: 10.32074/1591-951X-161

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Figure 9. — Differential diagnosis of GI aggressive T/NK-cells NHLs. EATL, MEITL and ENKTL, nasal type are aggressive T/NK lymphoid neoplasms of the GI tract. (A) EATL affects celiac patients and presents as polymorphous sheets of atypical T-cells with a rich inflammatory background (eosinophils, histiocytes and small lymphocytes). The uninvolved intestinal mucosa shows signs of enteropathy (H&E, upper right picture). Tumor cells are positive for various panT-cell markers and CD30, but lack CD8 and CD56. The ki67 index is high. (B) MEITL is an aggressive epitheliotropic NHL made of monomorphic atypical cells. CD3 is positive and highlights the striking epitheliotropism of tumor cells. CD8, CD56 and TIA1 are diffusely expressed, CD30 is negative (not shown) and the Ki-67 index is high. (C) ENKTL, nasal type is characterized by prominent angiotropism and diffuse positivity for EBER (large box, insert). It typically expresses cytoplasmic CD3, CD56 and cytotoxic markers (e.g. Granzyme B). The Ki67 index is high. (H&E, Giemsa and immunoperoxidase stain; original magnification 5x, 20x and 40x).