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. 2021 Mar;191(3):425–437. doi: 10.1016/j.ajpath.2020.09.004

Figure 2.

Figure 2

Optical coherence tomography (OCT) assessment and histopathology of retina in chronic uveitis. A and B: Retinal anatomy of B10.RIII (A) and C57BL/6 (B6; B) mice was evaluated by OCT in control (mice receiving CFA and Bordetella pertussis toxin without the peptide) and chronic uveitis mice at week 12. Representative images (left panels) and summary bar charts (right panels) are shown. Retinal thickness was measured from the interface of the vitreous (V) and the ganglion cell layer (GCL) to the interface between the retinal pigment epithelium (RPE) and choroid (CH). White bars in the images represent the normal retinal thickness in each mouse strain, which indicates the reduced thickness in mice with chronic uveitis. Asterisks indicate focal areas of thickening in both strains of chronic uveitis. C and D: Representative sections of hematoxylin and eosin–stained eyeballs at week 12 are shown. Characteristic changes in chronic uveitis in B10.RIII (C) and B6 (D) mice include the following: i) degeneration of the retinal pigment epithelium, the photoreceptor layer, and nuclear layers (asterisk); ii) retinal folds (hash mark); and iii) inflammatory infiltrates in the vitreous and choroid (arrows). Data are given as means ± SEM (A and B); n = 5 (A and B). ∗P < 0.05 versus control. Scale bars: 200 μm (C and D, top rows); 50 μm (C and D, bottom rows). INL, inner nuclear layer; ONL, outer nuclear layer; OpN, optic nerve; PRL, photoreceptor layer.