Figure 6.

Patients with COVID-19 with GI symptoms have reduced levels of circulating inflammatory cytokines. (A) Correlation matrix (Pearson) for 92 markers in the Olink panel across patients with any GI symptoms (top left) compared with no GI symptoms (top right) and patients with diarrhea (bottom left) compared with patients without diarrhea (bottom right). Cluster assignment is reported on the top of the heatmap. (B) Boxplot of Hallmark inflammatory response and KEGG JAK/STAT signaling pathway Z-scores stratified by GI symptoms that were significantly enriched at 10% FDR in cluster 4 and cluster 5, respectively. (C) Significant associations between proteomic clusters and GI symptoms at 10% (dark blue) and 15% (light blue) FDR based on unpaired 2-tailed t test. (D) Analytes associated with GI symptoms at 10% FDR based on unpaired t test. The intensity of the color is proportional to the –log₁₀P value. Negative associations are in blue, and positive associations are in red. On the right side of the heatmap, the cluster assignment for each marker is reported. (E) Boxplots represent the median and interquartile range of select differentially expressed markers stratified by GI symptoms. P values from the unpaired t test are reported.