Supplementary Table 11.
Association Between Diarrhea and Treatment in External Validation Cohort Using the Fisher Exact Test
| Treatment | Fisher exact P value | ||
|---|---|---|---|
| Hydroxychloroquine | .409 | ||
| Lopinavir.ritonavir | .466 | ||
| Darunavir.cobicistat | .473 | ||
| Tocilizumab | > .999 | ||
| Steroids | .698 | ||
| Ceftriaxone | .871 | ||
| Azithromycin | .209 | ||
| Piperacillin.Tazobactam | .837 | ||
| Statins | .609 | ||
| ACE.inhibitors | .052 | ||
| ARBs | .844 | ||
| Outcome | Quantiles | ||
| 2.50% | 50% | 97.50% | |
| Death | |||
| (Intercept) | 0.025 | 0.138 | 0.434 |
| diarrhea | 0.111 | 0.313 | 0.699 |
| treatment.Hydroxychloroquine | 0.170 | 0.706 | 2.965 |
| treatment.Lopinavir.ritonavir | 0.740 | 2.397 | 11.006 |
| treatment.Darunavir.cobicistat | 0.477 | 1.723 | 8.455 |
| treatment.Tocilizumab | 0.000 | 0.472 | 2.692 |
| treatment.Steroids | 0.000 | 1.626 | 7.849 |
| treatment.Ceftriaxone | 0.415 | 1.079 | 3.740 |
| treatment.Azithromycin | 0.252 | 0.651 | 1.462 |
| treatment.Piperacillin.Tazobactam | 0.961 | 3.014 | 11.740 |
| treatment.Statins | 0.981 | 2.261 | 5.127 |
| treatment.ACE.inhibitors | 0.588 | 1.503 | 3.413 |
| treatment.ARBs | 0.502 | 1.389 | 3.645 |
| ICU | |||
| (Intercept) | 8.89E–10 | 1.15E–08 | 3.40E–08 |
| diarrhea | 0.122 | 0.407 | 1.083 |
| treatment.Hydroxychloroquine | 1.52E–09 | 0.093814 | 1.265738 |
| treatment.Lopinavir.ritonavir | 33,992,289 | 318,000,000 | 4.11E+16 |
| treatment.Darunavir.cobicistat | 9669004 | 96256078 | 1.13E+16 |
| treatment.Tocilizumab | 3.17E–08 | 1.93167 | 11.84107 |
| treatment.Steroids | 0.557 | 4.866 | 46.290 |
| treatment.Ceftriaxone | 0.474 | 1.606 | 8.810 |
| treatment.Azithromycin | 0.264 | 0.719 | 1.756 |
| treatment.Piperacillin.Tazobactam | 0.097 | 0.807 | 6.591 |
| treatment.Statins | 0.140 | 0.580 | 1.655 |
| treatment.ACE.inhibitors | 0.192 | 0.683 | 2.022 |
| treatment.ARBs | 0.381 | 1.362 | 3.893 |
| ICU or death | |||
| (Intercept) | 0.054 | 0.219 | 0.674 |
| diarrhea | 0.126 | 0.297 | 0.585 |
| treatment.Hydroxychloroquine | 0.000 | 0.144 | 0.729 |
| treatment.Lopinavir.ritonavir | 4.142 | 22.183 | 215,000,000 |
| treatment.Darunavir.cobicistat | 2.143 | 11.491 | 102,000,000 |
| treatment.Tocilizumab | 0.000 | 1.198 | 7.012 |
| treatment.Steroids | 1.424 | 8.464 | 75,358,718 |
| treatment.Ceftriaxone | 0.559 | 1.304 | 4.167 |
| treatment.Azithromycin | 0.224 | 0.510 | 1.003 |
| treatment.Piperacillin.Tazobactam | 0.656 | 2.090 | 7.553 |
| treatment.Statins | 0.696 | 1.595 | 3.529 |
| treatment.ACE.inhibitors | 0.615 | 1.409 | 2.987 |
| treatment.ARBs | 0.668 | 1.642 | 4.449 |
NOTE. Association between diarrhea and outcome after adjustment for treatment based on the external validation cohort. Quantile of OR based on 1000 bootstrap iterations is reported.