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. 2021 Feb 18;10:519180. doi: 10.3389/fonc.2020.519180

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Copyright © 2021 Zhu, Tang, Lv, Meng, Weng, Zhang, Li, Fan, Zheng, Fang, Xu and Ji

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential expression analysis and identification of key apoptosis genes related to prognosis in HCC. (A) The heat map showed the expression levels of 14 apoptotic genes in HCC tissues and noncancerous tissues. (B) The histogram indicated the expression patterns of 14 apoptotic genes in HCC tissues and noncancerous tissues. (C) The volcano plot indicates that the 14 differentially expressed genes satisfy the condition of P < 0.05 and log FC > 1. (D) Univariate and multivariate Cox regression analysis performed to identify the genes closely associated with the prognosis of HCC patients. (E, F) qRCR was used to measure the mRNA level of CSE1L (E) and BAK1 (F) in human L02 hepatocytes and HCC cell lines. *P < 0.05; **P < 0.01; ****P < 0.0001.