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. 2020 Dec 16;10:592706. doi: 10.3389/fonc.2020.592706

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Copyright © 2020 Bravo-Cuellar, Ortiz-Lazareno, Sierra-Díaz, Solorzano-Ibarra, Méndez-Clemente, Aguilar-Lemarroy, Jave-Suárez, Ruiz Velazco-Niño and Hernández-Flores

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTX in combination with CIS increased PARP-1 cleavage in chemoresistant SiHa cells. Western blot analysis of PARP-1 in SiHaP and SiHaCIS-R cells were treated with CIS (30 μM), PTX (4 mM), or PTX + CIS for 24 h. Then, PARP cleavage was evaluated by Western blot (A). Densitometric analysis of total PARP-1 (B) and the cleavage of PARP (C) are shown. Relative density was calculated using Image Studio Lite ver. 5.2.5 (LI-COR Biotechnology) software. A representative example of three assays performed in triplicate is shown. β-Actin was used as a loading control. UCG, Untreated Control Group; CIS, CISplatin; PTX, PenToXifylline.