FIGURE 3.

CEC‐sEVs enhance anti‐OC effects of oxaliplatin and ameliorate oxaliplatin‐induced peripheral neuropathy in nude mice bearing s.c. OC tumor. [A schematic (a) shows the experimental design. Representative images of luciferase signals acquired by BLI of nude mice bearing s.c. SKOV3/luc xenografts (b) and quantitative data of relative tumor volumes (c) and tumor weight (d) show the OC tumor progression in nude mice with different treatments, respecitively. The quantitative data show the longitudinally monitoring of animal body weight (e). The quantitative data (f) show the longitudinally monitoring of symptoms of peripheral neuropathy and nerve conduction velocities in sciatic nerves, respectively, of nude mice that received different treatments. N indicates the animal numbers in each group. One‐way ANOVA with Tukey's multiple comparisons test was used. * P < 0.05 vs. control; #, P < 0.05 vs. oxa. Error bars indicate the standard error of the mean (SEM)]