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. 2021 Mar 4;10(5):e12073. doi: 10.1002/jev2.12073

FIGURE 4.

FIGURE 4

CEC‐sEVs enhanced anti‐OC effects of oxaliplatin and ameliorate oxaliplatin‐induced peripheral neuropathy in nude mice bearing i.p. OC tumor. [The quantitative data (a) show the longitudinally monitoring of symptoms of peripheral neuropathy and nerve conduction velocities in sciatic nerves, respectively, of nude mice bearing i.p. OVCAR3/luc xenografts and received different treatments. Representative ventral view images of luciferase signals acquired by BLI of nude mice (b) and quantitative data of relative tumor volume (c), total number of tumor nodules (d) and tumor weight (e) show the OC tumor progression in nude mice with different treatments. N indicates the animal numbers in each group. One‐way ANOVA with Tukey's multiple comparisons test was used. * P < 0.05 vs. control; #, P < 0.05 vs. oxa. Error bars indicate the standard error of the mean (SEM)]