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. 2021 Mar 4;10(5):e12073. doi: 10.1002/jev2.12073

FIGURE 5.

FIGURE 5

CEC‐sEVs reduce the damage to sciatic nerves and IENFs that are induced by oxaliplatin in nude mice. [Representative toluidine blue stain and TEM images (a) and the quantitative data of axon demyelination measured by G‐ratio (c) show the damage to axons in sciatic nerves of nude mice that received different treatments. The representative TEM images with enlarged areas of individual axons in sciatic nerves (b) and the quantitative data of vacuolated mitochondria (d) show the impairment of mitochondria in axons of sciatic nerves of nude mice that received different treatments. Representative confocal microscopic images and quantitative data of IENFs in footpad tissues of nude mice (e) show the lost of PGP9.5 positive IENFs (PGP9.5, red) in different groups. N in B and D indicates the number of axons were measured. One‐way ANOVA with Tukey's multiple comparisons test was used. *** P < 0.001 vs. control; ###, P < 0.001 vs. Oxa. Error bars indicate the standard error of the mean (SEM)]