FIGURE 9.

CEC‐sEVs alter oxaliplatin‐induced the changes of miRNAs and proteins in sciatic nerves and OC tumor. [qRT‐PCR results show the levels of miR‐15b, 214 and 125b in sciatic nerves (a) and OC tumor tissues (b), respectively, which were collected from nude mice that received different treatments. The schematic shows the miRNAs/target genes networks that contribute to the impairment of mitochondria in sciatic nerves (c) and OC cell apoptosis (d), respectively. Representative Western blot results and their quantitative data show the levels of proteins in sciatic nerves (e, g) and in OC tumor tissues (f, h), respectively. N indicates the number of replications. K indicates the molecular weight KDa. One‐way ANOVA with Tukey's multiple comparisons test was used. * P < 0.05 vs. control; #, P < 0.05 vs. oxa. Error bars indicate the standard error of the mean (SEM)]