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. 2021 Mar 4;10(5):e12073. doi: 10.1002/jev2.12073

FIGURE 11.

FIGURE 11

CEC‐sEVs carrying reduced miR‐214 substantially attenuate the effects of CEC‐sEVs on DRG axons and OC cells. [Quantitative RT‐PCR data (a) show that the levels of miR‐214‐3p were significantly decreased in CEC‐sEVs isolated from CECs transfected with lentiviral vector carrying shRNA against miR‐214 (Zipm214‐CEC‐sEVs) compared with CEC‐sEVs isolated from CECs transfected a scramble control vector (scra‐CEC‐sEVs). Quantitative data (b) show the effects of different concentration of Zipm214‐CEC‐sEVs (Zip‐sEVs) on growth cone extension of DRG neurons during a 24 h period (b) with or without oxaliplatin (9.1 nM). Quantitative data of MTT assay (c) show the effects of different concentration of Zipm214‐CEC‐sEVs on cell viability of OVCAR3 and SKOV3 cells under IC50 of oxaliplatin. N indicates the number of replications. One‐way ANOVA with Tukey's multiple comparisons test was used. * P < 0.05, *** P < 0.001 vs. control. Error bars indicate the standard error of the mean (SEM)]