FIGURE 1.

Activity‐based anorexia (ABA) can be reliably generated in wild‐type mice. Wheel revolutions per 15‐minute time bin over the course of 3 days in ABA are shown for female (a) and male (d) mice. Gray bars denote the dark cycle. Wheel revolutions during FAA, the four hours preceding food presentation, are shown in panels b (female, n = 8; *p = 0.0224) and E (male, n = 7; *p = 0.0334). Daily bodyweight expressed as a percentage of the animal's baseline average is shown in panels c and f for females and males, respectively. In both panels c and f, ****p < 0.0001. Summary data are presented as mean±SD. Data were analyzed using repeated measures one‐way ANOVA. Additional details are found in the results section