Table 3.
Baseline Risk Factors for Incident Liver Injury in Tuberculosis Patients Receiving Antiretroviral Therapy
| Univariable Analysis | Multivariable Analysis | |||
|---|---|---|---|---|
| Exposure Variable | HRa | P Value | aHRb | P Value |
| Treatment arm | ||||
| Sequential | Reference | … | Reference | … |
| Early integrated | 1.14 (0.77–1.69) | .526 | 1.19 (0.75–1.89) | .464 |
| Late integrated | 1.04 (0.69–1.56) | .855 | 1.17 (0.73–1.86) | .519 |
| Age (per 5-year increase) | 1.14 (1.04–1.24) | .006 | 1.19 (1.05–1.33) | .005 |
| Gender | ||||
| Female | Reference | … | Reference | … |
| Male | 1.43 (1.03–1.98) | .033 | 1.20 (0.79–1.82) | .399 |
| Body mass index, kg/m2 | ||||
| ≥18.5 | Reference | … | Reference | … |
| <18.5 | 0.90 (0.54–1.52) | .696 | 0.86 (0.49–1.50) | .592 |
| History of TB | ||||
| No | Reference | … | Reference | … |
| Yes | 1.00 (0.71–1.41) | .995 | 1.00 (0.67–1.48) | .996 |
| History of extrapulmonary TB | ||||
| No | Reference | … | Reference | … |
| Yes | 0.85 (0.35–2.07) | .721 | 0.68 (0.06–7.86) | .757 |
| World Health Organization stage | ||||
| 3 | Reference | … | Reference | … |
| 4 | 0.96 (0.45–2.04) | .908 | 0.68 (0.09–5.13) | .713 |
| Alcohol use | ||||
| Never used alcohol | Reference | … | Reference | … |
| History of alcohol use | 1.49 (0.99–2.25) | .059 | 1.34 (0.81–2.21) | .259 |
| CD4+ count (per 50 cells/mm3) | 0.99 (0.93–1.06) | .817 | 0.98 (0.90–1.06) | .538 |
| Hepatitis B surface antigen | ||||
| Negative | Reference | … | Reference | … |
| Positive | 1.79 (1.03–3.13) | .04 | 1.65 (0.88–3.07) | .116 |
Abbreviations: aHR, adjusted hazard ratio; HR, hazard ratio; TB, tuberculosis.
aRefers to hazard ratio (HR) as indicated in the footer.
bRefers to aHR-adjusted hazard ratio as indicated in the footer.