Table 2. Extracted data used for DALY calculations.

Arbovirus	Estimated global clinical cases per annum*	CFR (%)	Median age for fatal cases	Survivor’s risk for chronic or permanent disability	Median age for symptomatic disease	Duration of chronic disease (years)
CHIKV	52,774 to 328,943	0.07% (0.012% to 1.8%) [40,42,44]	60 [50]	42.5% (7.0% to 89.7%) [50–56]	39 [50–55]	2.0 (1.0 to 53) [50–56]
ZIKV	25,344 to 99,365	0.0023% (0.0020% to 0.0026%) [64,65]	72 [56]	(0.020%) (0.016% to 0.024%) [23–25]	40.5 [23–25]	1.0 (0.083 to 52) [22–24]
ZIKV (CZS)	372 to 795	29.9% (27.3% to 64.4%) [27,61]	0 [28,61]	100%†	0 [22–26,40–42]	92 (1.7 to 92) [28,30,31,66,67]

CFR, case fatality rate; CHIKV, chikungunya virus; CZS, congenital Zika syndrome; DALY, disability-adjusted life year; ZIKV, Zika virus.

*See S2 Table for complete listing of surveillance reports used to generate case count estimates.

^†Reported CZS cases are those that meet predefined international diagnostic criteria based on clinical symptoms. Current evidence suggests that these symptoms will persist throughout life; therefore, all of the CZS patients included in this analysis are assumed to have some degree of chronic or permanent disability [28,58,62].