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. 2021 Mar 4;16(3):e0246265. doi: 10.1371/journal.pone.0246265

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© 2021 Refat et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 14 — An electron micrograph of β-cells of the pancreatic tissues showing (A) control group showing β-cells with normal distinct intracellular spaces showing normal multi euchromatic rounded nuclei (N), normal sized mitochondria (M) with appearing of normal sized β-granules with an electron dense core (Red arrow) (Scale bar = 10μm). (B) STZ treated group showing detached pancreatic parenchyma (Black star) with reduced nucleus (RN) with disappearance of β-granules and appearance of some empty granules (Black arrow) with reduced sized mitochondria (Black arrow) (Scale bar = 5 μm). (C) STZ plus stem cell group showing restoration of pancreatic parenchyma with appearance of some small sized β-granules (Red arrow) with appearance of β-granular area (GR) with remaining of some Red blood corpuscles (R) and enlarged size mitochondria (M) than STZ group with appearance of nucleus (N) and appearance of some vacuoles (V) (Scale bar = 5 μm).(D) STZ plus (Q) group showing restoration of pancreatic parenchyma with appearance of multi small sized β-granules (Red arrow) with appearance of increased β-granular area (GR) with appearance of some vacuoles (Blue arrow) with appearance of euchromatic nucleus (N) (Scale bar = 5 μm). (E) STZ plus (Q/Zn) group showing restoration of pancreatic parenchyma with appearance of multi small sized β-granules and some enlarged sized β granules (Blue arrow) with appearance of increased β-granular area (GR) with appearance of some vacuoles (Blue arrow) with appearance of enlarges euchromatic nucleus (N) (Scale bar = 5 μm). (F) STZ plus (Q) and stem cells showing condensed euochromatic nucleus (N), with appearance of more rough endoplasmic reticulum (rER) and multi enlarged β-granules of islet of Langerhans (Red arrow) with normal sized mitochondria (M) and decreasing of β-granular spaces (Scale bar = 5 μm).(G) STZ plus (Q/Zn) and stem cells showing more restoration of β-granules of islet of langerhans with more condensed and enlarged β-granules and decreasing granular area space and appearance of rough endoplasmic reticulum (Scale bar = 5 μm).