Table 2. Univariate and multivariate analyses for recurrence in BCLC 0/A patients with HCC after curative hepatectomy.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| Variable | Comparison | N (%) | HR (95%CI) | P value | HR (95%CI) | P value |
| Age (years) | > 60 | 449 (52.4) | 1.333 (1.110–1.599) | 0.002 | ||
| ≦ 60 | 408 (47.6) | |||||
| Sex | Male | 670 (78.2) | 1.012 (0.812–1.263) | 0.913 | ||
| Female | 187 (21.8) | |||||
| DM | Yes | 222 (25.9) | 1.449 (1.186–1.770) | <0.001 | 1.357 (1.061–1.735) | 0.015 |
| No | 635 (74.1) | |||||
| Hypertension | Yes | 321 (37.5) | 1.350 (1.072–1.171) | 0.011 | ||
| No | 536 (62.5) | |||||
| Smoking | Yes | 242 (28.2) | 1.149 (0.864–1.528) | 0.340 | ||
| No | 615 (71.8) | |||||
| Alcohol | Yes | 182 (21.2) | 0.948 (0.691–1.300) | 0.741 | ||
| No | 675 (78.8) | |||||
| BMI | >25 | 360 (43.5) | 1.033 (0.821–1.299) | 0.784 | ||
| ≦25 | 468 (56.5) | |||||
| AST(U/L) | >40 | 320 (37.4) | 1.727 (1.439–2.072) | <0.001 | 1.356 (1.090–1.687) | 0.006 |
| ≦40 | 536 (62.6) | |||||
| ALT (U/L) | >40 | 372 (43.7) | 1.469 (1.225–1.762) | <0.001 | ||
| ≦40 | 479 (56.3) | |||||
| Total bilirubin | per mg/dL | 0.986 (0.604–1.610) | 0.956 | |||
| Serum creatinine | per mg/dL | 0.978 (0.912–1.049) | 0.533 | |||
| AFP (ng/mL) | > 200 | 158 (19) | 1.053 (0.829–1.337) | 0.673 | ||
| ≦ 200 | 674 (81) | |||||
| Platelet (109/L) | ≦ 150 | 439 (52) | 1.515 (1.261–1.819) | <0.001 | ||
| >150 | 406 (48) | |||||
| Albumin (g/dL) | ≦3 | 160 (18.8) | 1.770 (1.425–2.199) | <0.001 | 1.460 (1.140–1.869) | 0.003 |
| >3 | 689 (81.2) | |||||
| Liver cirrhosis | Yes | 400 (46.7) | 1.673 (1.395–2.007) | <0.001 | ||
| No | 457 (53.3) | |||||
| Child-Pugh grade | B | 71 (8.3) | 1.409 (1.002–1.943) | 0.036 | ||
| A | 786 (91.7) | |||||
| Tumor no. | Multiple | 77 (9) | 1.727 (1.306–2.284) | <0.001 | 1.731 (1.236–2.425) | 0.001 |
| Single | 780 991) | |||||
| Tumor size (cm) | per centimeter | 1.245 (1.155–1.800) | 0.001 | 1.298 (1.170–1.441) | <0.001 | |
| Histology stages | poor | 22 (2.6) | 2.561 (1.598–4.106) | <0.001 | ||
| well +moderate | 824 (97.4) | |||||
| Vascular invasion* | Yes | 320 (37.3) | 1.582 (1.314–1.903) | <0.001 | 1.631 (1.302–2.041) | <0.001 |
| No | 537 (62.7) | |||||
| Grade of steatosis | <5% (Reference) | 405 (53.9) | ||||
| 5–33% | 307 (40.9) | 1.129 (0.895–1.425) | 0.307 | |||
| >33% | 39 (5.2) | 0.895 (0.502–1.596) | 0.707 | |||
| Ishak fibrosis score | 4–6 | 419 (60.5) | 1.787 (1.416–2.256) | <0.001 | 1.730 (1.356–2.208) | <0.001 |
| 0–3 | 273 (39.5) | |||||
| Hepatitis B | Yes | 484 (56.5) | 1.148 (0.957–1.377) | 0.136 | 1.561 (1.093–2.229) | 0.014 |
| No | 373 (43.5) | |||||
| Hepatitis C | Yes | 300 (35) | 1.422 (1.182–1.711) | <0.001 | 1.866 (1.308–2.662) | 0.001 |
| No | 557 (65) | |||||
| Surgery | minor | 602 (70.2) | 0.889 (1.689–1.147) | 0.364 | ||
| major | 255 (29.8) | |||||
| Conventional | 757 (88.3) | 0.728 (0.518–1.023) | 0.067 | |||
| laparoscopic | 100 (11.7) | |||||
*2 patients are macrovascular invasion.