Table 1. Baseline characteristics of survivors and non-survivors, and univariate analysis.
| Parameters | Total (n = 2070) | Survivors (n = 1677) | Non-survivors (n = 393) | P values | Odds ratio (95% CI) |
|---|---|---|---|---|---|
| Age at diagnosis (years) | 67 (54–79) | 63 (51–75) | 81 (72–87) | <0.001 | |
| Age categorized | |||||
| ≤50 | 403 (19.48) | 392 (97.27) | 11 (2.73) | <0.001 | |
| 51–60 | 379 (18.32) | 360 (95.00) | 19 (5.00) | <0.001 | 1.88 (0.88–4.01) |
| 61–70 | 413 (19.96) | 363 (89.89) | 50 (12.11) | <0.001 | 4.91 (2.52–9.57) |
| 71–80 | 437 (21.12) | 325 (74.37) | 112 (25.63) | <0.001 | 12.28 (6.49–23.21) |
| >80 | 437 (21.12) | 237 (54.23) | 200 (45.77) | <0.001 | 30.07 (16.05–56.35) |
| Gender | |||||
| Female | 884 (42.71) | 740 (83.71) | 144 (16.29) | 0.008 | |
| Male | 1186 (57.29) | 938 (79.08) | 248 (20.92) | 0.008 | 1.36 (1.08–1.70) |
| Comorbidities- n (%) | |||||
| No | 752 (36.32) | 686 (91.20) | 66 (8.80) | <0.001 | |
| Yes | 1318 (63.68) | 992 (75.30) | 326 (24.70) | <0.001 | 3.42 (2.58–4.53) |
| Arterial hypertension- n (%) | |||||
| No | 1140 (55.37) | 1006 (88.24) | 134 (11.76) | <0.001 | |
| Yes | 919 (44.63) | 664 (72.25) | 255 (27.75) | <0.001 | 2.88 (2.29–3.63) |
| Diabetes mellitus- n (%) | |||||
| No | 1650 (80.13) | 1380 (83.63) | 270 (16.37) | <0.001 | |
| Yes | 409 (19.87) | 290 (70.90) | 119 (29.10) | <0.001 | 2.09 (1.63–2.69) |
| Obesity- n (%) | |||||
| No | 707 (70.56) | 588 (83.17) | 119 (16.83) | 0.664 | |
| Yes | 295 (29.44) | 242 (82.03) | 53 (17.97) | 0.664 | 1.08 (0.76–1.55) |
| Smoking- n (%) | |||||
| No | 1971 (95.86) | 1599 (81.13) | 372 (18.87) | 0.795 | |
| Yes | 85 (4.14) | 68 (80.00) | 17 (20.00) | 0.795 | 1.07 (0.62–1.85) |
| Cardiovascular disease- n (%) | |||||
| No | 1732 (84.24) | 1446 (83.49) | 286 (16.51) | <0.001 | |
| Yes | 324 (15.76) | 222 (68.51) | 102 (31.49) | <0.001 | 2.32 (1.78–3.03) |
| Pulmonary disease- n (%) | |||||
| No | 1716 (83.42) | 1406 (81.93) | 310 (18.07) | 0.028 | |
| Yes | 341 (16.58) | 262 (76.83) | 79 (23.17) | 0.028 | 1.37 (1.03–1.81) |
| Chronic kidney disease- n (%) | |||||
| No | 1665 (95.91) | 1439 (86.42) | 226 (13.58) | <0.001 | |
| Yes | 71 (4.09) | 42 (59.15) | 29 (40.85) | <0.001 | 4.39 (2.68–7.20) |
| Lymphocyte count (x109/l) (NR 1.2–5) | 1.00 (0.70–1.30) | 1.00 (0.70–1.40) | 0.80 (0.52–1.10) | 0.539 | |
| Platelet count (x109/l) (NR 140–450) | 209.00 (161.00–274.00) | 213.00 (104.00–277.25) | 195.50 (145.25–256.75) | <0.001 | |
| Thrombocytopenia | |||||
| No | 1701 (84.62) | 1411 (83.00) | 290 (17.00) | <0.001 | |
| Yes | 309 (15.38) | 223 (72.16) | 86 (27.84) | <0.001 | 1.87 (1.42–2.48) |
| PT (seconds) (NR 10–14) | 12.80 (12.10–13.80) | 12.80 (12.10–13.70) | 13.20 (12.40–14.30) | 0.001 | |
| Prolonged PT | |||||
| No | 1517 (80.35) | 1264 (83.32) | 253 (16.68) | <0.001 | |
| Yes | 371 (19.65) | 273 (73.58) | 98 (26.42) | <0.001 | 1.79 (1.37–2.34) |
| APTT (seconds) (NR 26–36) | 30.40 (28.10–32.70) | 30.50 (28.20–32.70) | 29.80 (27.40–33.00) | 0.549 | |
| Fibrinogen (mg/dl) (NR 200–400) | 677.00 (568.00–801.00) | 679.00 (570.00–801.00) | 677.00 (564.00–805.00) | 0.220 | |
| D-dimer levels (μg/l) (NR 70–500) | 623.50 (336.00–1106.50) | 562.00 (315.04–995.00) | 1046.00 (568.35–1976.00) | 0.001 | |
| Elevated D-dimer (>2 ULN) | |||||
| No | 1185 (70.62) | 1052 (88.77) | 133 (11.23) | <0.001 | |
| Yes | 493 (29.38) | 343 (69.57) | 150 (30.43) | <0.001 | 3.46 (2.66–4.50) |
| Ferritin levels (ng/ml) (NR 30–400) | 613.00 (314.00–1294.50) | 626.50 (354.50–1313.50) | 501.50 (241.00–1145.00) | 0.028 | |
| Ferritin elevated | |||||
| No | 373 (28.15) | 313 (83.91) | 60 (16.09) | 0.883 | |
| Yes | 952 (71.85) | 802 (84.24) | 150 (15.76) | 0.883 | 0.97 (0.70–1.35) |
APTT = activated partial Thromboplastin time; CI = confidence interval; dl = decilitre; l = litre; mg = miligrams; ml = mililitre; ng = nanograms; NR = normal range; PT = prothrombin time; ULN = upper limit of normal range. Missing data: age (1), lymphocyte count (60), platelet count (60), PT (182), APTT (176), fibrinogen (216), D-dimer levels (392), ferritin levels (1742).