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. 2021 Mar 4;16(3):e0248027. doi: 10.1371/journal.pone.0248027

Fig 5. Expression of Serpina3 in mouse brain stem.

Fig 5

Representative brain slice images of different ages 8 weeks (left), 30 weeks (middle), 52 weeks (right) of SAMR1(upper panel) and SAMP8 mice (lower panel). (A) SAMR1 (B) SAMP8. In the brain stem of SAMP8, immunoreactivity for Serpina3 (solid arrow) was observed in some astrocytic and neuronal cells of SAMP8, started from 8 weeks followed by 30 and 52 weeks, especially in 52 weeks old SAMP8, while that was not observed in the brain stem of SAMR1. In the brain stem of 52-week-old SAMP8, immunoreactivity for Serpina3 (solid arrow) was observed in some neuronal cells showing vacuolar degeneration (open arrow) (scale bar = 100 μm).