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. 2021 Feb 22;15(2):e0009016. doi: 10.1371/journal.pntd.0009016

Fig 5. Levels of cytokines detected in blood from marmosets infected with B. pseudomallei by the oral route.

Fig 5

A IFN-γ, B TNF-α, C MCP-1β (CCL4), D IL-6, E IL-2 F IL-17. Bars are median and interquartile range. Pre denotes pre-challenge blood samples, T is terminal disease (i.e. dose-ranging studies that succumbed to disease), S is survivors (i.e. dose-ranging studies that survived challenge). Statistical significance was determined by one-way ANOVA and is marked at the first time the cytokine level is significant compared to baseline (Pre) with P>0.05 *, P>0.01** and P>0.001***. All data is from Study 2, natural history study, except for the “Terminal” timepoint where data from animal’s challenged with between 6.2 and 6.8 x 106 cfu of B. pseudomallei has been included for comparison.