Table 2.

Hazard ratios (95% CIs) of Peripheral Neuropathy with All-cause and Cardiovascular Mortality in U.S. Adults Aged ≥ 40 years, NHANES, 1999–2004

	No Diabetes				With Diabetes
	Events/N	Incidence Rate per 1000 (95% CI)	Model 1 HR (95% CI)	Model 2 HR (95% CI)	Events/N	Incidence Rate per 1000 (95% CI)	Model 1 HR (95% CI)	Model 2 HR (95% CI)
All-cause mortality							Model 1	Model 2
No PN	1186/5037	13.0 (12.2–14.0)	1 (Ref)	1 (Ref)	314/838	27.4 (23.7–31.7)	1 (Ref)	1 (Ref)
With PN	430/905	34.3 (30.3–38.8)	1.40 (1.26–1.56)	1.37 (1.21–1.55)	210/357	58.0 (48.8–69.0)	1.79 (1.36–2.36)	1.72 (1.28–2.30)
Cardiovascular mortality
No PN	241/5037	2.4 (2.0–2.8)	1 (Ref)	1 (Ref)	85/838	7.7 (5.9–10.2)	1 (Ref)	1 (Ref)
With PN	104/905	7.3 (5.8–9.3)	1.40 (1.09–1.79)	1.32 (1.02–1.72)	62/357	19.8 (14.5–27.7)	2.11 (1.35–3.29)	2.04 (1.25–3.32)

Model 1: Adjusted for age, sex, and race-ethnicity

Model 2: Adjusted for variables in Model 1 plus education, BMI, smoking status, drinking status, cardiovascular disease, hypertension and hypercholesterolemia