Table 3.

Hazard Ratios (95% CIs) of All-cause and Cardiovascular Mortality with Duration of Diabetes and Peripheral Neuropathy in U.S. Adults Aged ≥ 40 years with Diabetes, NHANES, 1999–2004

	PN	Events/N	Incidence Rate per 1000 (95% CI)	Model 1 HR (95% CI)	Model 2 HR (95% CI)
All-cause mortality
Diabetes duration <10 years	No	178/555	22.0 (18.2–26.8)	1 (Ref)	1 (Ref)
Diabetes duration <10 years	Yes	87/172	49.3 (38.4–63.6)	1.80 (1.25–2.57)	1.62 (1.10–2.39)
Diabetes duration ≥10 years	No	134/281	39.4 (31.8–49.1)	1.50 (1.14–1.99)	1.37 (1.02–1.84)
Diabetes duration ≥10 years	Yes	121/180	68.3 (53.3–87.4)	2.53 (1.84–3.49)	2.42 (1.75–3.33)
Cardiovascular mortality
Diabetes duration <10 years	No	45/555	5.5 (3.8–8.3)	1 (Ref)	1 (Ref)
Diabetes duration <10 years	Yes	21/172	11.3 (6.5–21.4)	1.57 (0.67–3.69)	1.40 (0.58–3.33)
Diabetes duration ≥10 years	No	39/281	12.3 (8.5–18.4)	1.87 (1.02–3.44)	1.56 (0.85–2.86)
Diabetes duration ≥10 years	Yes	46/180	29.5 (19.9–44.8)	4.13 (2.26–7.56)	3.82 (2.12–6.88)

Model 1: Adjusted for age, sex and race-ethnicity

Model 2: Adjusted for variables in Model 1 plus education, BMI, smoking status, drinking status, cardiovascular disease, hypertension and hypercholesterolemia