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. 2021 Feb 19;10:e63524. doi: 10.7554/eLife.63524

Figure 6. Conformational changes upon ATP binding.

Figure 6.

(A, B) The tweezer-like motion of the nucleotide binding domains (NBDs). Transmembrane domains (TMDs) are shown as surface representations; NBDs are displayed as ribbons. The two pinning helices are highlighted as cylinders. ATPs are shown as sticks. (C) The twisting motion of TMD1. The two structures are superpositioned based on NBD1. The ATP-bound form is shown in blue and ATP-free conformation in gray. The rotation axis of TMD1 and the helical subdomain is indicated in magenta. (D) Closing of the TM cavity upon TMD1 twisting. The structures are aligned based on TMD2. ATP-bound TMDs are shown in blue and green; ATP-free conformation is shown in gray.