Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 4;10:e64563. doi: 10.7554/eLife.64563

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021, Keenen et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

PMC Copyright notice

Figure 9. — (A) At the microscopic scale, interactions between the terminal extensions and hinge domain toggles HP1α between autoinhibited and active states. DNA biases HP1α to the active state. (B) At the intermediate scale, HP1α and DNA cluster into proto-condensates. (C) If HP1α is present above the critical concentration, proto-condensates aggregate into large macroscopic droplets characterized by liquid behavior of HP1α and static DNA held in sub-condensate domains. (D) At genomic loci, HP1α condensates are remodeled by forces, resisting and strengthening in response to instantaneous forces, but relaxing and weakening in response to sustained forces. HP1α domains are also subject to disruption and reinforcement from HP1-interacting proteins like HP1β.