Table 1.
Demographic and clinical features of CD patients.
| All cases | Wild type (WT) | Polymorphism carriers (etero+omo) | |
|---|---|---|---|
| Number of patients | 191 | 125 | 66 |
| Age of onset (yrs) | 27 (21.5-38.5) | 28 (23-43.5) | 25 (19.25-34)∗ |
| Δ diagnosis-surgery (months) | 12 (6-36) | 12 (5-40) | 12 (6-36) |
| Gender | |||
| Male | 110 (58%) | 68 (54%) | 42 (64%) |
| Female | 81 (42%) | 57 (46%) | 24 (36%) |
| Smoking habit | |||
| No | 57 (33%) | 31 (28%) | 26 (44%)∗ |
| Yes | 54 (32%) | 35 (31%) | 19 (32%) |
| Former | 60 (35%) | 46 (41%) | 14 (24%) |
| Pack years | 15 (6-27) | 18 (10-35) | 9 (5-18)∗∗ |
| Disease location | |||
| Ileo | 112 (59%) | 74 (59%) | 38 (57%) |
| Colon | 20 (10%) | 15 (12%) | 5 (8%) |
| Ileocolon | 59 (31%) | 36 (29%) | 23 (35%) |
| Disease behavior | |||
| Inflammatory | 20 (11%) | 13 (10%) | 7 (11%) |
| Stricturing | 84 (44%) | 57 (46%) | 27 (41%) |
| Fistulising | 18 (9%) | 10 (8%) | 8 (12%) |
| Stricturing and fistulising | 69 (36%) | 45 (36%) | 24 (36%) |
| Extraintestinal disease | |||
| Skin | 27 (14%) | 19 (15%) | 8 (12%) |
| Arthritis | 60 (31%) | 41 (33%) | 19 (29%) |
| Perianal fistulae | 65 (34%) | 39 (31%) | 26 (39%) |
| Medication responsiveness | |||
| Mesalazine | 140 (92%) | 94 (93%) | 46 (88%) |
| Steroids | 126 (81%) | 80 (81%) | 46 (82%) |
| Azathioprine | 73 (72%) | 44 (72%) | 29 (73%) |
| Infliximab | 33 (57%) | 20 (54%) | 13 (62%) |
| Adalimumab | 46 (75%) | 24 (75%) | 22 (76%) |
| Type of surgery | |||
| Resection | 157 (82%) | 100 (80%) | 55 (83%) |
| Resection+SXPL | 34 (18%) | 25 (20%) | 11 (17%) |
| Recurrence | 99 (52%) | 64 (51%) | 35 (53%) |
| Multiple operations (≥2) | 99 (52%) | 63 (50%) | 36 (55%) |
| History of urgent surgery | 47 (25%) | 32 (26%) | 15 (23%) |
| Minimum surgery-free interval (yrs) | 3 (0.5-9) | 3 (0.5-8) | 3 (0.2-13.5) |
| Mean surgery-free interval (yrs) | 5 (2-9) | 5 (2-8) | 5 (2-13.5) |
| Digestive cancer | 5 (3%) | 3 (2%) | 2 (3%) |
| Extraintestinal cancer | 9 (5%) | 7 (6%) | 2 (3%) |
| Immunological comorbidity | |||
| Autoimmunity | 26 (14%) | 17 (14%) | 9 (14%) |
| Asthma | 8 (4%) | 4 (3%) | 4 (6%) |
| Allergies | 49 (26%) | 28 (22%) | 21 (32%) |
| Familial IBD | 42 (26%) | 29 (27%) | 13 (24%) |
| Disease status | |||
| Quiescent | 95 (66%) | 56 (62%) | 39 (74%) |
| Active | 49 (34%) | 35 (38%) | 14 (26%) |
Data are median (interquartile range 25–75) for continuous variables and number (percentage) for categorical variable. ∗p < 0.05, ∗∗p < 0.01 WT vs. etero+omo, by χ2 or Mann–Whitney test.