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. 2021 Feb 11;49:101188. doi: 10.1016/j.molmet.2021.101188

Figure 2.

Figure 2

CD81 expression levels gradually reduced in β-cells during development. (A–D) Violin plots indicating Cd81 expression levels in different pancreatic cell types at different developmental stages. (E) FACS counter plots representing P21 islets isolated from the Nkx6-1-VF mouse line and stained for CD81; the left plot displays the separation of two clusters based on the Venus fluorescence intensity; in the right plot, Nkx6-1-VF+ cells are separated based on CD81 expression levels. (F) Time course FACS analysis of CD81 expression levels in β-cells using the Nkx6-1-VF mouse line (N = 3 for P4 and N = 4 for the rest). (G) Representative image of dispersed β-cells isolated from Nkx6-1-VF islets stained for CD81 and Venus. Yellow asterisks mark CD81low/- β-cells, while white asterisks label CD81high β-cells. Scale bar 20 μm.