Fig. 6. Anti-angiogenic therapy is effective in ERO1-devoid breast tumors.
A Bioluminescence signals of primary breast tumors and lungs from representative mice orthotopically-injected with WT and ERO1 KO MDA-MB231m, and treated three times with the anti-VEGF, B20 or vehicle. B Bioluminescence signals of ex vivo lungs. C Primary breast tER stress response mediator induced by hypoxia. Its lack impairsumor and (D) lymph node growth. E Dot plots on a logarithmic scale of the bioluminescence counts of lungs after B20 or vehicle treatment.