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. 2021 Jan 19;40(9):1609–1627. doi: 10.1038/s41388-020-01638-9

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© The Author(s), under exclusive licence to Springer Nature Limited 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The heat map from RNA sequencing analysis showing the top 100 differentially expressed lncRNAs in hypoxic BT549 cells compared with normoxic BT549 cells. b Expression of 11 randomly selected upregulated lncRNAs were verified by qRT-PCR in hypoxic BT549 cells compared with normoxic BT549 cells. c qRT-PCR was performed to determine the lncRNA KB-1980E6.3 expression in various hypoxic breast cancer cells compared with that in normoxic breast cancer cells. d The heights of the columns in the chart represent the log2-transformed fold changes (tumor vs normal) in lncRNA KB-1980E6.3 expression in 71 paired breast cancer tissues and adjacent non-cancerous tissues. e The relative log2-transformed fold changes (tumor vs normal) of lncRNA KB-1980E6.3 in 71 cases of breast tumors with different clinical stages were measured by qRT-PCR. f, g The lncRNA KB-1980E6.3 expression levels in non-paired (f) or paired (g) breast tumor tissues and normal tissues based on the RNA-seq data extracted from the TCGA database. h Kaplan–Meier survival analysis of overall survival according to the lncRNA KB-1980E6.3 expression levels based on TCGA cohort. Data are shown as mean ± SD of three independent experiments (**P < 0.01; ***P < 0.001).