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. 2021 Jan 19;40(9):1609–1627. doi: 10.1038/s41388-020-01638-9

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© The Author(s), under exclusive licence to Springer Nature Limited 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b Knockdown or overexpression efficiencies of lncRNA KB-1980E6.3 were assessed by qRT-PCR analysis. c The volcano plot showing the differential genes between lncRNA KB-1980E6.3 overexpressing tumor cells and their control cells under normoxia conditions. d The heat map showing the top 100 upregulated genes between lncRNA KB-1980E6.3 overexpressing tumor cells and their control cells under normoxia conditions. e KEGG pathway analysis of differentially expressed genes in (c). Representative genes were shown in the right panel. f–h Mammosphere formation abilities were assessed in lncRNA KB-1980E6.3 knockdown and control breast cancer cells. Representative images of spheres, mammosphere numbers, and mammosphere sizes are shown in (f), (g), and (h), respectively. Scale bar, 100 μm. i Tumor initiation incidence in nude mice injected with indicated sphere cells from Hs578T shNC or shKB under administration of bevacizumab (10 mg/kg). Data are shown as mean ± SD of three independent experiments (**P < 0.01; ***P < 0.001).