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. 2021 Jan 19;40(9):1609–1627. doi: 10.1038/s41388-020-01638-9

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© The Author(s), under exclusive licence to Springer Nature Limited 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b c-Myc mRNA levels in lncRNA KB-1980E6.3 knockdown BT549 and Hs578T cells under hypoxia conditions (a) or lncRNA KB-1980E6.3 overexpressing BT549 and Hs578T cells under normoxia conditions (b). c, d The protein levels of c-Myc, KLF4, SOX2, OCT4, and Nanog in lncRNA KB-1980E6.3 knockdown BT549 and Hs578T cells under hypoxia conditions (c) or lncRNA KB-1980E6.3 overexpressing BT549 and Hs578T cells under normoxia conditions (d). e The heights of the columns in the chart represent the log2-transformed fold changes (tumor vs normal) in c-Myc expression in 71 paired breast cancer tissues and adjacent non-cancerous tissues (left panel). The relative log2-transformed fold changes (tumor vs normal) of c-Myc in 71 cases of breast tumors with different clinical stages were measured by qRT-PCR (right panel). f The correlation between c-Myc mRNA and lncRNA KB-1980E6.3 expression levels in breast cancer patients based on the data from TCGA database. g Representative IHC staining images showing c-Myc protein levels in lncRNA KB-1980E6.3 high or low tumor tissues (left panel). Scale bar, 50 μm. LncRNA KB-1980E6.3 levels in the lncRNA KB-1980E6.3 high or low tumor groups (right panel). h The correlation between lncRNA KB-1980E6.3 RNA level and c-Myc protein IHC scores. Data are shown as mean ± SD of three independent experiments (**P < 0.01; ***P < 0.001).