Table 4.

Effect of each NSAID variable on CV risk adjusting covariates

Model variable	Categories	Risk ratio (95% CI)	P value
Duration of NSAIDs treatment	vs. < 1 year
	> 1 to ≤ 3	1.03 (0.81, 1.32)	0.8148
	> 3 to ≤ 5	0.84 (0.50, 1.39)	0.4861
	> 5	1.92 (1.05, 3.52)	0.0346
Consistent use of NSAIDs	Consistent use of NSAIDs (percentage of supply days ≥ 70%) vs. < 70%	1.18 (0.85, 1.62)	0.3257
Mode of administration	vs. oral
	Patch	1.20 (0.67, 2.14)	0.5347
	Other	1.04 (0.70, 1.54)	0.8598
	Combination use	0.86 (0.70, 1.55)	0.3324

Each NSAIDs variable was tested respectively using models adjusted for covariates of age, gender, baseline comorbidities of GI, renal disease, hypertension, other CV disease, and diabetes mellitus all together

CI confidence interval, CV cardiovascular, GI gastrointestinal, NSAIDs nonsteroidal anti-inflammatory drugs