Patients with heart failure (HF) with reduced ejection fraction often have multiple comorbidities and receive concomitant medications

Vericiguat coadministered with sacubitril/valsartan (SV), aspirin (acetylsalicylic acid), or warfarin was well tolerated, with no clinically relevant pharmacodynamic or pharmacokinetic interactions observed

These findings support concomitant use of SV, aspirin, or warfarin, commonly used by patients with HF, with vericiguat