Table 3 .
Univariate analysis of FGFR2-positive patients determined by FISH and RNAseq results (N = 355). The analysis was limited to ICC and PCC
| Positive (N = 23) |
Negative (N = 332) |
P value | |
|---|---|---|---|
| Sex | |||
| Male | 19 | 225 | 0.167 |
| Female | 4 | 107 | |
| Age | |||
| > 65 | 6 | 184 | 0.009 |
| ≤ 65 | 17 | 148 | |
| Tested tumor specimen | |||
| Resection | 7 | 118 | 0.822 |
| Biopsy | 16 | 214 | |
| Percutaneous biopsy | 13 | 164 | |
| EUS-FNA | 2 | 24 | |
| Endoscopic biopsy | 1 | 26 | |
| Stage | |||
| Metastasis | 13 | 168 | 0.124 |
| Recurrence | 8 | 77 | |
| Locally advanced | 2 | 87 | |
| Differentiation | |||
| Poorly | 1 | 61 | 0.178 |
| Moderate/well | 9 | 129 | |
| Unknown | 13 | 142 | |
| Primary site | |||
| ICC | 20 | 252 | 0.311 |
| PCC | 3 | 80 | |
| Macroscopic typea | |||
| Mass forming | 20 | 219 | 0.221 |
| Periductal infiltrating | 0 | 27 | |
| Intraductal growth | 0 | 1 | |
| Unknown | 0 | 5 | |
| Smoking history | |||
| Positive | 17 | 204 | 0.372 |
| Negative | 6 | 122 | |
| Unknown | 0 | 6 | |
|
Alcohol abuse (ethanol/day) | |||
| ≥ 60 g | 7 | 38 | 0.060 |
| < 60 g | 16 | 289 | |
| Unknown | 0 | 5 | |
| HCV Ab and/or HBs Ag | |||
| Either positive | 6 | 30 | 0.020 |
| Others | 17 | 302 | |
| Pancreaticobiliary maljunction | |||
| + | 0 | 1 | 1.0 |
| − | 23 | 331 | |
| PSC | |||
| Positive | 0 | 1 | 1.0 |
| Negative | 23 | 331 | |
| Printing industry | |||
| Positive | 0 | 3 | 1.0 |
| Negative | 23 | 317 | |
| Unknown | 0 | 12 | |
| Cholelithiasis | |||
| + | 1 | 21 | 1.0 |
| − | 22 | 311 | |
| Family history about malignant tumor | |||
| + | 11 | 172 | 0.830 |
| − | 12 | 160 | |
EUS-FNA endoscopic ultrasound-fine needle aspiration, PSC primary sclerosing cholangitis
aFor macroscopic type, only ICC was analyzed