Rosacea has been reported to be associated with various gastrointestinal diseases including inflammatory bowel disease, celiac disease, irritable bowel syndrome, gastroesophageal reflux disease, Helicobacter pylori infection, and small intestine bacterial overgrowth.

Among rosacea-associated gastrointestinal diseases, the evidence for inflammatory bowel disease is the strongest.

The link between rosacea and gastrointestinal comorbidities may involve common predisposing genetic, microbiota, and immunological factors, comprising the theory of the gut–skin axis.

The associations of rosacea with gastrointestinal diseases remind us of these possible comorbidities and provide an innovate direction for treating rosacea, and conventional therapy for which is usually unsatisfactory because of frequent relapses.