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. 2021 Feb 4;56(3):193–217. doi: 10.1007/s00535-020-01746-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Step 2 of the IBS Therapeutic Algorithm. This step is indicated for IBS patients with moderate severity who do not respond to gut-targeted pharmacotherapy. For further details see the main text. Detailed examination described in the legend of Fig. 1 may be part of this step depending on the clinical demand