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. 2019 Nov 19;42(1):47–57. doi: 10.1007/s10974-019-09566-2

Table 1.

Kinetic parameters of mouse and human ventricular myofibrils following replacement by exchange of the endogenous cTn complex with human recombinant cTn

Myofibril type kACT (s−1) kTR (s−1) Slow kREL (s−1) Fast kREL (s−1)
Mouse Ventr (control) 7.35 ± 0.54 7.12 ± 0.61 1.45 ± 0.21 28.3 ± 2.9
Mouse Ventr (human cTn exchanged) 7.05 ± 0.44 6.92 ± 0.75 1.55 ± 0.28 25.3 ± 3.1
Human Ventr (human cTn exchanged) 0.84 ± 0.03 0.78 ± 0.04 0.30 ± 0.02 4.65 ± 0.19

Data are mean ± SEM; n ≥ 10. Data from human cTn exchanged mouse myofibrils and control (sham-treated) mouse myofibrils are unpublished data; data from human cTn exchanged human ventricular myofibrils are from Piroddi et al. (2019). The exchange protocol allows replacement of 70–90% of the endogenous cTn complex