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Natural killer (NK) cell and cDC1 cross-talk. NK cells secrete XCL1, CCL4, and CCL5 which attract XCR1 and CCR5 expressing cDC1s. Moreover, NK cells produce FLT3L, a differentiation factor for precursor DCs to cDC1s recruit NK cells via CXCL9-11 secretion into the TME. In a positive feedback loop, IL-12 produced by cDC1s activates IFN-γ extraction by NK cells, which again increases IL-12 secretion by cDC1s.
