Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 19;11:631713. doi: 10.3389/fimmu.2020.631713

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Bödder, Zahan, van Slooten, Schreibelt, de Vries and Flórez-Grau

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Possible immunotherapeutic approach targeting natural killer (NK) cells and cDC1s. Interfering with the XCR1-XCL1 axis in the tumor could increase antigen-specific CD8+ T cell infiltration. The intranodal reinfusion of cDC1s from patients after isolation them from PBMCs, maturation, and antigen-loading could be an ex vivo approach. In vivo, intratumoral XCL1 injection could recruit cDC1s into the tumor. Injected or attracted cross-presenting cDC1s in the tumor enhance CD8+ T cells activation. Monoclonal antibodies initiate antibody-dependent cellular cytotoxicity (ADCC) by NK cells leading to increased cross-presentation of tumor-cell derived antigens by cDC1s.