Table 4.
Baseline values and changes of clinical and SEP measures in response to different rTMS interventions (affected arm)
| Measure | Baseline (avg. across the 3 sessions) | High frequency rTMS session | Low frequency rTMS session | Sham rTMS session | |||
|---|---|---|---|---|---|---|---|
| Change at Post 1 | Change at Post 2 | Change at Post 1 | Change at Post 2 | Change at Post 1 | Change at Post 2 | ||
| Clinical | |||||||
| 2pt. discrimination* (mm) | 12.5 (5.0) | −0.7 (2.7) | −1.7 (3.5) | −0.5 (1.8) | −0.3 (1.2) | −0.1 (1.3) | 0.1 (2.1) |
| Monofilament | 5.0 (1.8) | 0.6 (1.6) | 0.6 (1.3) | −0.1 (1.3) | −0.1 (1.2) | 0.3 (0.6) | 0.4 (0.8) |
| Proprioception (% correct) | 71.7 (26.4) | 2.3 (24.8) | 2.5 (32.0) | 4.4 (13.8) | 9.3 (13.3) | 1.2 (15.4) | 4.1 (22.7) |
| Vibration (V) | 9.7 (9.3) | 2.4 (6.1) | 1.7 (4.9) | 1.5 (5.0) | −0.2 (3.2) | −0.4 (7.6) | −0.5 (4.4) |
| SEP | |||||||
| N20 latency* (msec) | 16.3 (10.3) | −1.1 (2.3) | 0.1 (2.0) | 0.1 (2.2) | −1.8 (5.8) | 0.7 (3.0) | 1.2 (2.5) |
| P25 latency | 21.3 (13.6) | −1.7 (5.5) | −1.6 (3.1) | −1.3 (1.9) | −3.1 (8.3) | −0.1 (5.1) | −0.7 (4.1) |
| N33 latency | 27.8 (18.2) | −4.2 (6.5) | −2.0 (5.5) | −0.7 (3.0) | 0.8 (5.6) | −0.1 (7.0) | −0.8 (4.8) |
| P45 latency | 35.1 (23.6) | 0.9 (15.2) | 0.9 (18.1) | −2.1 (5.9) | 1.9 (4.3) | 2.8 (9.8) | 0.2 (7.4) |
| N60 latency* | 49.5 (35.7) | 3.0 (20.7) | 3.2 (19.6) | −7.1 (22.6) | −4.9 (22.5) | 6.6 (15.1) | −0.1 (20.8) |
| P100 latency* | 80.6 (48.0) | 2.1 (25.4) | −0.6 (9.0) | 4.1 (15.1) | 1.0 (9.6) | 14.7 (19.3) | 5.6 (15.9) |
| N120 latency | 107.4 (63.3) | −21.2 (59.5) | −6.4 (22.5) | 4.8 (11.9) | −0.2 (20.4) | −7.5 (51.2) | −10.4 (51.7) |
| N20-P25 amplitude (μV) | 0.8 (1.6) | −0.1 (0.6) | 0.1 (0.5) | 0.1 (0.3) | −0.0 (0.3) | 0.1 (0.3) | 0.1 (0.3) |
| P25-N33 amplitude | 0.9 (1.5) | −0.0 (0.5) | 0.4 (1.0) | −0.1 (0.3) | −0.1 (0.3) | 0.1 (0.5) | 0.1 (0.3) |
| N33-P45 amplitude* | 0.9 (1.3) | 0.2 (0.5) | 0.5 (1.0) | −0.0 (0.3) | 0.1 (0.3) | 0.2 (0.5) | 0.1 (0.5) |
| P45-N60 amplitude* | 1.1 (1.4) | 0.2 (1.0) | 0.4 (0.9) | −0.3 (0.6) | −0.3 (1.4) | 0.3 (0.9) | 0.0 (0.5) |
| N60-P100 amplitude | 0.8 (0.7) | −0.2 (0.8) | −0.2 (0.9) | −0.1 (0.4) | 0.0 (0.4) | −0.1 (0.5) | 0.0 (0.2) |
| P100-N120 amplitude | 0.5 (0.6) | −0.4 (1.0) | −0.3 (1.0) | −0.1 (0.4) | −0.0 (0.3) | −0.0 (0.4) | −0.0 (0.1) |
All values are expressed as mean (standard deviation)
*
Indicates the variable that demonstrated statistical significance in the mixed model analysis at p ≤ 0.05
Change at Post 1 = testing value at Baseline at each session minus testing value at Post 1 data collection
Change at Post 2 = testing value at Baseline at each session minus testing value at Post 2 data collection