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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Cancer Discov. 2020 Dec 2;11(3):591–598. doi: 10.1158/2159-8290.CD-20-1165

Fig. 1: Genomic differences in LUAD across patient populations.

Fig. 1:

A) TMB, SCNA burden and the frequency of KRAS mutations are lower, while the frequency of EGFR mutations is higher, in lung cancers from East Asian patients, compared to lung cancers from patients of European and/or African origin. The somatic EGFR mutation rate in lung cancer varies among Latin American countries. Mexican and Colombian populations have varying degrees of admixed NAT ancestry, as indicated in blue. B) Both germline variations and environmental exposures such as smoking can predispose to somatic alterations driving the development of lung cancers, that may cause the genomic differences across populations.