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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Cancer Discov. 2020 Nov 6;11(3):736–753. doi: 10.1158/2159-8290.CD-20-0519

Figure 6. Ablation of tumor cell intrinsic KLF5, SMAD4 and EGFR increases the sensitivity of PDA tumors to a combination immunotherapy.

Figure 6.

A, Growth curves, waterfall plots, and overall survival curves of WT, Klf5-KO, Smad4-KO, Egfr-KO tumors with or without GAFCP treatment. Tumor cells were subcutaneously implanted into C57BL/6 mice (2 knockout tumor cell clones were pooled together for this experiment, n=5/group). In A, statistical differences were calculated using two-way ANOVA with multiple analysis (tumor growth curves) and Log-rank (Mantel-Cox) test (survival curves).