Table 3.
Prediction of AUDIT scores at baseline as a function of familial risk.
| Familial risk N = 866 | No familial risk N = 793 | |||||
|---|---|---|---|---|---|---|
| Variables | Standardized beta | p | Standardized beta | p | ||
| LEQ (sexuality, deviance) | 0.153 | (0.086–0.219) | 0.000 | 0.068 | (−0.001–0.137) | 0.054 |
| SURPS hopelessness | 0.100 | (0.033–0.167) | 0.003 | 0.098 | (0.034–0.162) | 0.003 |
| MCQ discounting | 0.047 | (−0.014–0.108) | 0.134 | 0.015 | (−0.046–0.076) | 0.632 |
| TCI impulsivity | 0.003 | (−0.053–0.057) | 0.931 | 0.045 | (−0.017–0.107) | 0.160 |
| NEO extraversion | 0.073 | (0.004–0.142) | 0.038 | 0.063 | (0.002–0.128) | 0.057 |
| WISC-IV PRI | −0.047 | (−0.120–0.021) | 0.177 | −0.017 | (−0.074–0.045) | 0.617 |
| WISC-IV VCI | 0.002 | (−0.058–0.058) | 0.947 | 0.028 | (−0.042–0.105) | 0.419 |
| CGT risk-taking | 0.013 | (−0.049–0.075) | 0.682 | −0.035 | (−0.095–0.025) | 0.252 |
| SNP risk score | −0.003 | (−0.066–0.060) | 0.926 | 0.019 | (−0.041–0.079) | 0.535 |
| SES | −0.010 | (−0.069–0.050) | 0.754 | 0.002 | (−0.068–0.072) | 0.948 |
| Baseline smoking | 0.336 | (0.271–0.401) | 0.000 | 0.477 | (0.410–0.544) | 0.000 |
| MID Insula anticipation | −0.027 | (−0.097–0.043) | 0.449 | −0.014 | (−0.082–0.054) | 0.686 |
| MID VS anticipation | −0.051 | (−0.127–0.025) | 0.189 | 0.103 | (0.028–0.178) | 0.007 |
| MID VMPFC anticipation | 0.047 | (−0.021–0.114) | 0.172 | −0.049 | (−0.117–0.019) | 0.157 |
| MID Insula outcome | 0.000 | (−0.000–0.000) | 0.998 | 0.048 | (−0.015–0.111) | 0.137 |
| MID VS outcome | −0.056 | (−0.132–0.020) | 0.147 | −0.001 | (−0.046–0.045) | 0.969 |
| MID VMPFC outcome | 0.003 | (−0.051–0.057) | 0.920 | −0.093 | (−0.160 to −0.027) | 0.006 |
| SST OFC | 0.011 | (−0.074–0.096) | 0.799 | −0.009 | (−0.083–0.065) | 0.814 |
| SST rIFG | −0.023 | (−0.106–0.060) | 0.588 | −0.057 | (−0.136–0.022) | 0.157 |
| Prenatal cigarette consumption | 0.018 | (−0.046–0.082) | 0.578 | −0.029 | (−0.080–0.042) | 0.538 |
| Prenatal alcohol consumption | 0.069 | (0.007–0.130) | 0.028 | 0.098 | (0.038–0.157) | 0.001 |
AUDIT Alcohol Use Disorder Identification Test, LEQ Life Events Questionnaire, SURPS Substance Use Risk Profile Scale, TCI Temperament and Character Inventory, NEO Revised NEO Personality Inventory—NEO PI-R, WISC-IV Wechsler Intelligence Scale for Children—Fourth Edition, PRI perceptual reasoning index, VCI verbal comprehension index, CGT Cambridge Gambling Task, SNP single nucleotide polymorphisms, SES socioeconomic status, FH family history, MID Monetary Incentive Delay, VS ventral striatum, VMPFC ventromedial prefrontal cortex, SST Stop Signal Task, OFC orbitofrontal cortex, rIFG right inferior frontal gyrus, familial risk R2 = 0.224, no familial risk R2 = 0.315.