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. 2021 Mar 4;11:5154. doi: 10.1038/s41598-021-84647-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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USP7 co-localizes with TAL1, E2A, and HEB in the Jurkat cell line. (A) Density heatmap showing that the majority of the peaks from TAL1, E2A, and HEB ChIP-seq overlap with those of USP7. (B) Representative TAL1, HEB, E2A, and USP7 peaks proximal to the CD69 gene body. (C) Representative TAL1, HEB, E2A, and USP7 peaks proximal to the RAG1/2 gene body. (D) Affinity purification-mass spectrometry using USP7 and TAL1 as bait proteins. Venn diagram (left) shows the overlap of USP7 and TAL1 interacting proteins. P-value was calculated based on a two-sided Fishers-exact test. Spectral counts of USP7 and TAL1 interacting proteins are shown on the right. (E) Serial co-IP Western blotting showing the interaction of USP7/TAL1 and E proteins.