Table 2.
Synovial fluid and serum IL-8 associations with clinical severity, inflammatory markers and adipokines in synovial fluid and blood.
| Synovial fluid IL-8a | Serum IL-8b | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Adjustedc | Univariate | Adjustedc | |||||
| PCC [95% CI] | p value | PCC [95% CI] | p value | PCC [95% CI] | p value | PCC [95% CI] | p value | |
| Clinical severity | ||||||||
| Lequesne | 0.291 [0.108, 0.455] | 0.002 | 0.237 [0.045, 0.411] | 0.016 | 0.095 [− 0.093, 0.277] | 0.320 | 0.101 [− 0.091, 0.287] | 0.301 |
| KOOS pain | − 0.216 [− 0.389, − 0.029] | 0.024 | − 0.201 [− 0.380, − 0.008] | 0.041 | − 0.028 [− 0.213, 0.160] | 0.774 | − 0.029 [− 0.219, 0.162] | 0.764 |
| KOOS symptoms | − 0.221 [− 0.393, − 0.033] | 0.021 | − 0.209 [− 0.387, − 0.017] | 0.034 | − 0.076 [− 0.258, 0.112] | 0.431 | − 0.071 [− 0.258, 0.121] | 0.469 |
| KOOS function | − 0.205 [− 0.380, − 0.017] | 0.032 | − 0.185 [− 0.365, 0.009] | 0.062 | − 0.059 [− 0.243, 0.128] | 0.536 | − 0.059 [− 0.247, 0.133] | 0.548 |
| Inflammatory markers | ||||||||
| TNF-α | 0.332 [0.143, 0.498] | < 0.001 | 0.334 [0.140, 0.503] | 0.001 | 0.082 [− 0.106, 0.265] | 0.390 | 0.094 [− 0.099, 0.279] | 0.340 |
| IL-6 | 0.455 [0.291, 0.594] | < 0.001 | 0.461 [0.293, 0.602] | < 0.001 | − 0.064 [− 0.248, 0.123] | 0.502 | − 0.034 [− 0.223, 0.158] | 0.729 |
| Adipokines | ||||||||
| Leptin | 0.076 [− 0.119, 0.266] | 0.445 | 0.006 [− 0.193, 0.204] | 0.955 | − 0.058 [− 0.241, 0.130] | 0.547 | − 0.036 [− 0.225, 0.156] | 0.718 |
| Adiponectin | 0.095 [− 0.095, 0.279] | 0.326 | 0.124 [− 0.071, 0.310] | 0.211 | 0.068 [− 0.120, 0.251] | 0.481 | 0.044 [− 0.148, 0.233] | 0.654 |
| Resistin | 0.201 [0.012, 0.376] | 0.037 | 0.182 [− 0.012, 0.362] | 0.066 | 0.010 [− 0.176, 0.196] | 0.914 | 0.024 [− 0.168, 0.214] | 0.809 |
| Visfatin | 0.256 [0.070, 0.424] | 0.007 | 0.194 [0.000, 0.373] | 0.049 | 0.037 [− 0.151, 0.222] | 0.702 | 0.037 [− 0.155, 0.226] | 0.708 |
| Osteopontin | 0.593 [0.455, 0.703] | < 0.001 | 0.575 [0.430, 0.692] | < 0.001 | 0.059 [− 0.129, 0.242] | 0.542 | 0.066 [− 0.126, 0.254] | 0.502 |
aSynovial fluid associations between IL-8 with inflammatory markers and adipokines.
bSerum associations between IL-8 with inflammatory markers and adipokines.
KOOS Knee injury and Osteoarthritis Outcome Score, SF synovial fluid, IL-8 interleukin-8, IL-6 interleukin-6, TNF-α Tumor Necrosis Factor-alpha.
cEffects adjusted by measurement batch and by potential confounders: age, OA evolution time, KL grade and BMI. KL Kellgren–Lawrence scale, BMI Body Mass Index. Statistical significant associations are in bold type. PCC partial correlation coefficient. 95% CI interval at 95% confidence.
Statistically significant results are highlighted in bold.