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. 2021 Mar 4;11:5238. doi: 10.1038/s41598-021-84804-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Results of the ALE meta-analysis. The highlighted clusters (C1–C8) represent significant convergence about grey matter differences in AUD patients compared to healthy controls. (a) Clusters are depicted on brain slices of an MNI standard brain. Color indicates ALE value. (b) Spatial position and expansion of the ALE-clusters depicted on a grey matter glass brain. Cluster-forming threshold p < 0.001, family wise error (FWE) cluster level corrected at p < 0.05. x, y and z values refer to coordinates in MNI space, for detailed MNI peak voxel coordinates of the ALE clusters see Table 2. This image was created with Mango v4.1. (http://ric.uthscsa.edu/mango/).