Table 1.
Demographic and clinical sample characteristics of the studies included in the ALE meta-analysis.
| # | Source | AUD patients | Duration of AUD in years M (SD) | Duration of abstinence d/w/mo, M (SD) | Healthy controls | |||
|---|---|---|---|---|---|---|---|---|
| n (Fem.) | Age, M (SD) | Diagnosis (diagnosis criteria) | n (Fem.) | Age, M (SD) | ||||
| 1 | Asensio et al.66 | 24 (0) | 35.62 (4.81) | Alc. Abuse (DSM-IV) | 4.71 (2.93) | 40.88 d (29.07) | 24 (0) | 31.91 (9.34) |
| 2 | Bach et al.67 | 74 (19) | 46.5 (10.0) | Alc. Dependence (DSM) | 13.6 (10.0) | n.a. | 43 (16) | 46.5 (9.2) |
| 3 | Bach et al.50 | 62 (14) | 47.6 (9.7) | Alc. Dependence (DSM-IV) | n.a. | 11.77 d (9.03) | 74 (16) | 44.12 (9.6) |
| 4 | Chanraud et al.19 | 26 (0) | 47.7 (7.1) | Alc. Dependence (DSM-IV) | 8 (6.3) | 26.4 w (29.0) | 24 (0) | 45.0 (6.72) |
| 5 | Chanraud et al.51 | 24 (0) | 47.8 (7.7) | Alc. Dependence (DSM-IV) | 9.2 (8.9) | 31.0 w (31.0) | 24 (0) | 45.0 (5.6) |
| 6 | Charlet et al.43 | 40 (10) | 44.9 (11.4) | Alc. Dependence (DSM-IV) | 8.95 (9.1) | 11.95 d (5.55) | 40 (10) | 44.1 (12.0) |
| 7 | Demirakca et al.20 | 50 (23) | 46.6 (8.2) | Alc. Dependence (DSM-IV, ICD-10) | 12.4 (7.4) | 16.5 d (7.3) | 66 (32) | 45.0 (10.1) |
| 8 | Galandra et al.52,85 | 23 (9) | 45.69 (7.82) | Alc. Dependence (DSM-V) | 10.8 (7.21) | ≥ 10 d | 18 (7) | 44.83 (8.86) |
| 9 | Galandra et al.53 | 22 (9) | 45.59 (7.99) | Alc. Dependence (DSM-IV) | 11.89 (7.11) | ≥ 10 d | 18 (8) | 44.83 (8.86) |
| 10 | Grodin et al.21 | 37 (16) | 40.2 (9.2) | Alc. Dependence (DSM-IV) | 10.3 (7.5) | 21.5 d (5.3) | 69 (22) | 36.6 (1.1) |
| 11 | Guggenmos et al.54 | 119 (18) | 45.0 (10.7) | Alc. Dependence (DSM-IV, ICD-10) | 11.7 (9.9) | 22.8 d (11.5) | 97 (16) | 43.7 (10.8) |
| 12 | Jang et al.55 | 20 (0) | 43.5 (6.0) | Alc. Dependence (DSM-IV) | n.a. | 7.8 d (6.5) | 20 (0) | 44.5 (7.4) |
| 13 | Mechtcheriakov et al.22 | 22 (8) | 53.6 (n.a.) | Alc. Addiction (ICD-10) | n.a. | n.a. | 22 (8) | 53.7 (n.a.) |
| 14 | Nurmedov et al.68 | 24 (4) | 40.79(9.807) | Alc. Use Disorder (DSM5) | 7.7 (4.75) | ≥ 3 d | 29 (6) | 37.45 (10.871) |
| 15 | Pitel et al.42 | 34 (6) | 43.47 (8.36) | Alc. Dependence (DSM-IV) | 16.09 (10.29) | 12.67 d (6.94) | 25 (14) | 43.88 (11.24) |
| 16 | Rando et al.56 | 45 (10) | 38.20 (7.74) | Alc. Dependence (DSM-IV) | n.a. | 35.12 d (7.3) | 50 (22) | 31.14 (9.04) |
| 17 | Reiter et al.57 | 43 (9) | 44.42(10.21) | Alc. Dependence (DSM-V, ICD-10) | 14.64 (9.96) | 28.8 d (11.85) | 35 (10) | 42.0 (10.49) |
| 18 | Ritz et al.41 | 17 (4) | 44.35 (9.17) | Alc. Dependence (DSM-IV) | 9.17 (7.14) | 16.25 d(23.29) | 16 (4) | 45.44 (7.14) |
| 19 | Rosenthal et al.65 | 46 (16) | 44.56(11.18) | Alc. Dependence (DSM-IV) | n.a. | n.a. | 39 (23) | 42.74(11.69) |
| 20 | Segobin et al.58 | 19 (2) | 44.40 (6.07) | Alc. Dependence (DSM-IV) | 8.22 (8.79) | 11.05 (5.20) | 20 (n.a.) | 46.7 (4.25) |
| 21 | Trick et al.59 | 29 (11) | 40.4 (9.55) | Alc. Dependence (DSM-IV) | n.a. | ≥ 2 w | 31 (15) | 40.2 (8.7) |
| 22 | Van Eijk et al.60 | 49 (9) | 47.0 (10.1) | Alc. Dependence (DSM-IV, ICD-10) | n.a. | 1 d | 55 (13) | 45.3 (11.9) |
| 23 | van Holst et al.23 | 36 (0) | 43.2 (11.03) | Alc. Abuse or Dependence (DSM-IV) | 11.69 (9.7) | 18 d (n.a.) | 54 (0) | 35.3 (10.1) |
| 24 | Wang et al.61 | 20 (0) | 43.95 (6.30) | Alc. Dependence (DSM-IV) | n.a. | 41.5 d (10.80) | 20 (0) | 40.50 (8.17) |
| 25 | Dong et al.62 | 56 (0) | 43.36 (8.6) | Alc. Dependence (DSM-IV) | n.a. | 50.58 d (n.a.) | 33 (0) | 42.88 (6.05) |
| 26 | Wiers et al.63 | 22 (0) | 42.14 (6.2) | Alc. Dependence (DSM-IV) | 14.82 (7.4) | 48.32 d (46.95) | 21 (0) | 41.95 (6.41) |
| 27 | Zois et al.64 | 95 (24) | 45.9 (9.9) | Alc. Dependence (DSM-IV) | 10.9 (8.9) | 11.69 d (6.66) | 87 (16) | 45.9 (10.6) |
AUD = alcohol use disorder, Fem. = females, d/w/mo = days/weeks/months, n.a. = information not available.