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. 2021 Mar 4;11:5267. doi: 10.1038/s41598-021-84443-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of α-syn alters levels of proteins involved in iron-homeostasis. (a) Representative Western blots of iron-related proteins (ferritin, α-syn, TfR1, and DMT1) in the indicated xenograft lysates. (b–d) Quantitative analysis of fold changes in ferritin, TfR1 and DMT1, derived from densitometric analysis of band intensities normalized to α-tubulin. P-values were determined using a one-way ANOVA with Dunnett posthoc test (n = 3). (e) Representative Western blots of ferroportin (FPN1) and α-syn in the indicated xenograft lysates. (f) Quantitative analysis of the fold change in FPN1, derived from densitometric analysis of band intensities normalized to α-tubulin. P-values were determined using a one-way ANOVA with Dunnett posthoc test (n = 3). Error bars in each plot are ± s.d. Uncropped sections of blots are shown in Supplementary Figure S5.